Insights
Podcasts, research, and perspectives from PL Neuro.
PL BCI Roadmap Series: Roadmap 2 — Expanding Neurotechnology to Consumer Products
PL Neuro Team
The second roadmap in Protocol Labs' BCI Roadmap Series examines how neurotechnology can expand beyond the clinic into consumer products — the technical, regulatory, and market steps required to bring brain–computer interfaces to everyday users at scale.
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Konrad Kording — The Power of a Single Neuron and Simulating the Brain
Juan Benet
How neurons actually compute, and why the path to understanding the brain runs through reading its wiring — not just recording it. New episode with Dr. Konrad Kording, professor of bioengineering and neuroscience at the University of Pennsylvania and co-director of CIFAR's Learning in Machines & Brains program. Konrad works at the intersection of causality, […]
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Tom Oxley — BCI Without Opening the Skull, the Race With China, and the 2040s
Juan Benet
Reaching the brain through its blood vessels, restoring autonomy to people who've lost it, and the future of BCIs after movement. New episode with Dr. Tom Oxley, co-founder and CEO of Synchron. Synchron has built a BCI called the Stentrode, which reaches the motor cortex via a blood vessel — leveraging the approach of cardiovascular […]
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Jacques Carolan — The Mission to Get Breakthrough Brain Treatments to Everyone
Juan Benet
Biohybrid interfaces, closed-loop gene therapies, and the push to put transformative brain technology in every clinic. Episode 3 features Dr. Jacques Carolan, a founding Program Director at ARIA, the UK's Advanced Research and Invention Agency. He directs two neurotech programs aimed at one of the most important opportunity spaces: developing tools and systems to interface, […]
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Ben Rapoport — Treating Paralysis and Digitizing Neural Data
Juan Benet
Precision Neuroscience’s co-founder and CSO on building Layer 7, a BCI that sits on the surface of the brain, and why neural data is the new genomics. Ben is co-founder and CSO of Precision Neuroscience, Assistant Professor of Neurosurgery at the Icahn School of Medicine at Mount Sinai, and Scientific Director at Mount Sinai. Previously, […]
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How to Obtain a Complete Human Connectome at Synaptic Resolution Within the Next Decade
PL Neuro Team
A roadmap for mapping every synaptic connection in the human brain within ten years. In this preprint, Moritz Helmstaedter — Director at the Max Planck Institute for Brain Research — lays out a roadmap for obtaining a complete human connectome at synaptic resolution within the next decade: the technical, methodological, and infrastructural steps the field […]
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Max Hodak — Restoring Sight, Growing Neurons on Silicon, and Expanding Human Intelligence
Juan Benet
How a silicon chip is giving blind patients their sight back — and what comes next for the human brain. Max Hodak is the founder and CEO of Science Corp (previously co-founded Neuralink and Transcriptic). Science is building PRIMA, a retinal prosthetic that’s restoring meaningful vision for patients with blindness caused by age-related macular degeneration. […]
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Representations #1 — BCI, Neural Data & Business Innovation in Neurotech's NeuroAI Era
Naveen Rao
The first issue of Representations — a limited series on neurotech's evolving business frontier, produced in partnership with PL Neuro. If BCI companies are data companies, and data companies are AI companies, are BCI companies becoming AI companies?
Read →Compiling Molecular Ultrastructure into Neural Dynamics
Konrad P. Kording et al.
A proposal for an 'ultrastructure-to-dynamics compiler': a learned mapping from molecularly annotated brain ultrastructure to simulator-ready, uncertainty-aware physiological parameters — turning anatomical maps into predictive models of circuit dynamics.
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PL BCI Roadmap Series: Roadmap 1 — Smoothing the Path to Clinical Revenue
PL Neuro Team
The first roadmap in Protocol Labs' BCI Roadmap Series examines how brain–computer interface companies can smooth the path to clinical revenue — the reimbursement, regulatory, and go-to-market steps that turn breakthrough devices into sustainable businesses.
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PL BCI Roadmap Series: Overview — A Strategic Vision for the Future of Brain–Computer Interfaces
PL Neuro Team
The opening report in Protocol Labs' Brain–Computer Interface Roadmap Series, laying out a strategic vision for where the field is headed and the bottlenecks that must be cleared to get there.
Read →Cognitive Dark Matter: Measuring What AI Misses
Patrick Mineault
A proposal that the jagged intelligence of modern AI stems from a missing training signal — 'cognitive dark matter': brain functions that shape behavior yet are hard to infer from behavior alone. The paper outlines data types that could surface it for model training.
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